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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK2
All Species:
20.61
Human Site:
T59
Identified Species:
32.38
UniProt:
O96017
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96017
NP_001005735.1
543
60915
T59
S
S
H
S
S
S
G
T
L
S
S
L
E
T
V
Chimpanzee
Pan troglodytes
XP_001172779
543
60866
T59
S
S
H
S
S
S
G
T
L
S
S
L
E
T
V
Rhesus Macaque
Macaca mulatta
XP_001102484
543
60923
T59
S
S
H
S
S
S
G
T
L
S
S
L
E
T
V
Dog
Lupus familis
XP_543464
544
61233
S59
A
P
T
S
S
Q
S
S
H
S
S
S
G
T
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z265
546
61070
T68
S
S
H
S
S
S
G
T
L
S
S
L
E
T
V
Rat
Rattus norvegicus
NP_446129
545
60912
T67
S
S
H
S
S
S
G
T
L
S
S
L
E
T
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508699
537
60493
E59
Q
D
L
P
S
I
P
E
D
Q
E
P
E
E
P
Chicken
Gallus gallus
NP_001073576
522
58779
D59
E
L
P
S
I
P
E
D
P
E
P
D
E
L
V
Frog
Xenopus laevis
NP_001082016
517
58243
D60
E
D
P
E
I
D
E
D
I
P
Q
P
W
G
R
Zebra Danio
Brachydanio rerio
Q501V0
422
47914
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61267
476
54243
I42
L
Y
G
K
N
I
K
I
K
S
L
G
T
S
S
Honey Bee
Apis mellifera
XP_624334
480
54300
P45
R
L
C
P
S
K
L
P
F
R
T
M
E
M
T
Nematode Worm
Caenorhab. elegans
Q9U1Y5
476
53320
A42
V
G
E
S
Q
C
A
A
S
K
P
F
A
K
L
Sea Urchin
Strong. purpuratus
XP_794585
480
52849
P45
L
S
S
M
E
T
I
P
T
Q
E
V
A
E
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39009
513
58614
G59
N
R
N
V
T
T
I
G
R
S
R
S
C
D
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
89.3
N.A.
83.1
83.4
N.A.
74.4
67.5
59.6
28.1
N.A.
34
37.2
30.2
43.2
Protein Similarity:
100
99.8
99
93
N.A.
89.7
89.9
N.A.
82.1
77.9
73.1
41.9
N.A.
51.5
54.5
49.5
58.3
P-Site Identity:
100
100
100
33.3
N.A.
100
100
N.A.
13.3
20
0
0
N.A.
6.6
13.3
6.6
6.6
P-Site Similarity:
100
100
100
53.3
N.A.
100
100
N.A.
13.3
20
6.6
0
N.A.
20
26.6
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
7
7
0
0
0
0
14
0
0
% A
% Cys:
0
0
7
0
0
7
0
0
0
0
0
0
7
0
0
% C
% Asp:
0
14
0
0
0
7
0
14
7
0
0
7
0
7
0
% D
% Glu:
14
0
7
7
7
0
14
7
0
7
14
0
54
14
0
% E
% Phe:
0
0
0
0
0
0
0
0
7
0
0
7
0
0
0
% F
% Gly:
0
7
7
0
0
0
34
7
0
0
0
7
7
7
7
% G
% His:
0
0
34
0
0
0
0
0
7
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
14
14
14
7
7
0
0
0
0
0
0
% I
% Lys:
0
0
0
7
0
7
7
0
7
7
0
0
0
7
0
% K
% Leu:
14
14
7
0
0
0
7
0
34
0
7
34
0
7
14
% L
% Met:
0
0
0
7
0
0
0
0
0
0
0
7
0
7
0
% M
% Asn:
7
0
7
0
7
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
7
14
14
0
7
7
14
7
7
14
14
0
0
7
% P
% Gln:
7
0
0
0
7
7
0
0
0
14
7
0
0
0
0
% Q
% Arg:
7
7
0
0
0
0
0
0
7
7
7
0
0
0
7
% R
% Ser:
34
40
7
54
54
34
7
7
7
54
40
14
0
7
7
% S
% Thr:
0
0
7
0
7
14
0
34
7
0
7
0
7
40
7
% T
% Val:
7
0
0
7
0
0
0
0
0
0
0
7
0
0
47
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% W
% Tyr:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _